The journal Archiv der Pharmazie published an article entitled "Synthesis and Evaluation of new nitrofuranylamides with collection of Mycobacterium tuberculosis clinical strains from multidrug-resistant tuberculosis high-burden country," co-authored by Igor Mokrousov (corresponding author) and Anna Vyazovaya.
The emergence of drug-resistant Mycobacterium tuberculosis strains necessitates the development of new therapeutic agents. The study investigated the activity of novel piperazine derivatives of nitrofuranylamides against a large collection of Russian clinical strains representing globally prevalent genotypes and various drug-resistance profiles. Structure-activity relationship analysis revealed that the nature of aromatic substituents in N-aryl-substituted piperazine nitrofuranylamides plays a key role in their in vitro activity. An additional nitro group in compound No. 14 likely significantly enhances its activity. A non-synonymous mutation in the efflux pump gene Rv3728 (372A>V, GCC>GTC), identified in one of the Haarlem genotype strains, may correlate with its high level of resistance to nitrofurans.
Archiv der Pharmazie has been published continuously since 1822; it is currently the official journal of the German Pharmaceutical Society and is published by John Wiley & Sons (USA). The journal has acceptance rate of 27%.
References:
Archiv der Pharmazie: https://en.wikipedia.org/wiki/Archiv_der_Pharmazie
John Wiley & Sons: https://en.wikipedia.org/wiki/Wiley_(publisher)
Article: https://onlinelibrary.wiley.com/doi/10.1002/ardp.70355