The “International Journal of Mycobacteriology” has published the article "Highly- and Low-virulent Mycobacterium tuberculosis Strains of the Beijing Genotype Elicit Contrasting Immune Response in C57BL/6 Mice as Revealed by Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-alpha Distinct Expression," co-authored by Institute scientists Igor Mokrousov (corresponding author) and Anna Vyazovaya.
Innate immunity plays a significant role in the progression of tuberculosis (TB) and its transition to an active form. Mycobacterium tuberculosis is capable of altering molecular pathways within the host, thereby suppressing the immune response and facilitating infection development. The study aimed to identify immunohistochemical markers in the lungs of mice infected with M. tuberculosis strains that differ in their phylogenetic and pathobiological characteristics. The authors concluded that disease progression and lung tissue damage in the mice were associated with a pronounced immune response, elevated iNOS synthesis, and strain-specific properties that reduce TNF-α production. iNOS and TNF-α can serve as molecular markers of the immune response, characterizing the differences between highly and low-virulent *M. tuberculosis* strains in a mouse model.
The “International Journal of Mycobacteriology” is published by Wolters Kluwer (Netherlands) and is indexed in PubMed, Scopus, and Web of Science.
Link to the article: Krylova, Y., Dokhov, M., Panfilova, A., Vyazovaya, A., Vinogradova, T., Kvetnoy, I., & Mokrousov, I. (2026). Highly- and Low-virulent Mycobacterium tuberculosis Strains of the Beijing Genotype Elicit Contrasting Immune Response in C57BL/6 Mice as Revealed by Inducible Nitric Oxide Synthase and Tumor Necrosis Factor-alpha Distinct Expression. International Journal of Mycobacteriology, 15(3), 245–254. https://doi.org/10.4103/ijmy.ijmy_102_26