A team of scientists from St. Petersburg Pasteur Institute published an article in the Journal of Infectology. The article analyzes variants of the TRIM5 gene in HIV-infected patients.
The authors studied two polymorphic variants of this gene, which encodes the TRIM5α protein, a key factor in innate immunity that limits HIV replication in the early stages. The results showed that the studied genetic variants are associated differently with the risk of HIV infection: one is associated with increased susceptibility, while the other is associated with a protective effect. These data confirm the importance of host genetic characteristics in the development of the infectious process.
This study highlights the need to consider population specificity when assessing individual risk and opens up prospects for further study of the role of TRIM family proteins in the pathogenesis of HIV infection.
This is one of the first studies to characterize these markers in the Russian population. Yulia Ostankova, Vladimir Davydenko, Aleksander Shchemelev, Areg Totolian.